Proteins/UNIPROT:Q9P0K1

ADAM22

ProteinUNIPROT:Q9P0K1

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1..

Function from UniProtKB (Q9P0K1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

developmental and epileptic encephalopathy has a germline basis in ADAM22DiseaseGenCC HGNC:201|MONDO:0100620Inferred only
developmental and epileptic encephalopathy, 61 has a germline basis in ADAM22DiseaseGenCC HGNC:201|MONDO:0033370Inferred only

Statements

18 statements

18 statements · 3 reference databases · Subject: ADAM22 · Sources: gene ontology, Hetionet, Reactome

Order

ABI2 interacts with ADAM22ProteinHetionet hetionet:interacts:10152-53616Inferred only
EPS8 interacts with ADAM22ProteinHetionet hetionet:interacts:2059-53616Inferred only
HCK interacts with ADAM22ProteinHetionet hetionet:interacts:3055-53616Inferred only
LGI1 interacts with ADAM22ProteinHetionet hetionet:interacts:53616-9211Inferred only
MYB interacts with ADAM22ProteinHetionet hetionet:interacts:4602-53616Inferred only
RAC2 interacts with ADAM22ProteinHetionet hetionet:interacts:53616-5880Inferred only
YWHAB interacts with ADAM22ProteinHetionet hetionet:interacts:53616-7529Inferred only
YWHAE interacts with ADAM22ProteinHetionet hetionet:interacts:53616-7531Inferred only
YWHAH interacts with ADAM22ProteinHetionet hetionet:interacts:53616-7533Inferred only
YWHAQ interacts with ADAM22ProteinHetionet hetionet:interacts:10971-53616Inferred only
YWHAZ interacts with ADAM22ProteinHetionet hetionet:interacts:53616-7534Inferred only
ADAM22 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only

Show the remaining 6

ADAM22 participates in LGI-ADAM interactionsPathwayReactome R-HSA-5682910Inferred only
ADAM22 regulates negative regulation of cell adhesionBiological processgene ontology Q9P0K1|GO:0007162Inferred only
ADAM22 regulates positive regulation of synaptic transmissionBiological processgene ontology Q9P0K1|GO:0050806Inferred only
ADAM22 regulates regulation of AMPA glutamate receptor clusteringBiological processgene ontology Q9P0K1|GO:1904717Inferred only
ADAM22 regulates regulation of AMPA receptor activityBiological processgene ontology Q9P0K1|GO:2000311Inferred only
ADAM22 regulates regulation of synapse assemblyBiological processgene ontology Q9P0K1|GO:0051963Inferred only

Other names

4 names

Resolves to: ADAM22

Also called: ADAM 22MDC2Metalloproteinase-disintegrin ADAM22-3Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2

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