Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q08043

ACTN3

Protein·UNIPROT:Q08043

Open in the graph

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Function from UniProtKB (Q08043), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

25 statements

25 statements · 4 reference databases · Subject: ACTN3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

ACTN2 interacts with ACTN3ProteinHetionet hetionet:interacts:88-89Inferred only
ACTN4 interacts with ACTN3ProteinHetionet hetionet:interacts:81-89Inferred only
ACTN3 interacts with ADORA2AProteinHetionet hetionet:interacts:135-89Inferred only
ACTN3 interacts with MYPNProteinHetionet hetionet:interacts:84665-89Inferred only
ACTN3 interacts with NRAPProteinHetionet hetionet:interacts:4892-89Inferred only
ACTN3 interacts with UBCProteinHetionet hetionet:interacts:7316-89Inferred only
ACTN3 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
ACTN3 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
ACTN3 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
ACTN3 participates in Nephrin family interactionsPathwayReactome R-HSA-373753Inferred only
ACTN3 participates in Striated Muscle ContractionPathwayReactome R-HSA-390522Inferred only
ACTN3 participates in Striated muscle contraction pathwayPathwayWikiPathways WP383Inferred only

Show the remaining 13

ACTN3 regulates negative regulation of calcineurin-NFAT signaling cascadeBiological processgene ontology Q08043|GO:0070885Inferred only
ACTN3 regulates negative regulation of cold-induced thermogenesisBiological processgene ontology Q08043|GO:0120163Inferred only
ACTN3 regulates negative regulation of glycolytic processBiological processgene ontology Q08043|GO:0045820Inferred only
ACTN3 regulates negative regulation of oxidative phosphorylationBiological processgene ontology Q08043|GO:0090324Inferred only
ACTN3 regulates negative regulation of relaxation of muscleBiological processgene ontology Q08043|GO:1901078Inferred only
ACTN3 regulates positive regulation of bone mineralization involved in bone maturationBiological processgene ontology Q08043|GO:1900159Inferred only
ACTN3 regulates positive regulation of fast-twitch skeletal muscle fiber contractionBiological processgene ontology Q08043|GO:0031448Inferred only
ACTN3 regulates positive regulation of glucose catabolic process to lactate via pyruvateBiological processgene ontology Q08043|GO:1904025Inferred only
ACTN3 regulates positive regulation of skeletal muscle fiber developmentBiological processgene ontology Q08043|GO:0048743Inferred only
ACTN3 regulates positive regulation of skeletal muscle tissue growthBiological processgene ontology Q08043|GO:0048633Inferred only
ACTN3 regulates regulation of aerobic respirationBiological processgene ontology Q08043|GO:1903715Inferred only
ACTN3 regulates regulation of apoptotic processBiological processgene ontology Q08043|GO:0042981Inferred only
ACTN3 regulates regulation of the force of skeletal muscle contractionBiological processgene ontology Q08043|GO:0014728Inferred only

Other names

2 names

Resolves to: ACTN3

Also called: Alpha-actinin skeletal muscle isoform 3F-actin cross-linking protein

← Every protein Find it in the graph →