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A reference for what the literature reports. Not medical advice.

Proteins/UNIPROT:Q96I13

ABHD8

Protein·UNIPROT:Q96I13

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Negatively regulates NLRP3-driven inflammation. Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation..

Function from UniProtKB (Q96I13), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

2 statements

2 statements · 2 reference databases · Subject: ABHD8 · Sources: gene ontology, Hetionet

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COL27A1 covaries with ABHD8ProteinHetionet hetionet:covaries:79575-85301Inferred only
ABHD8 regulates negative regulation of NLRP3 inflammasome complex assemblyBiological processgene ontology Q96I13|GO:1900226Inferred only

Other names

2 names

Resolves to: ABHD8

Also called: Abhydrolase domain-containing protein 8Alpha/beta hydrolase domain-containing protein 8

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