Pathway
VxPx cargo-targeting to cilium
A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).
What the reference databases state
Statements
21 statements
21 statements · 1 reference database · Subject: VxPx cargo-targeting to cilium · Sources: Reactome
- ARF4 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- ASAP1 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- CNGA2 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- CNGA4 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- CNGB1 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC1 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC2 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC3 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC4 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC5 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC6 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- EXOC7 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
Show the remaining 9
- EXOC8 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- GBF1 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- PKD1 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- PKD2 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- RAB11A participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- RAB11FIP3 participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- RAB3IP participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- RAB8A participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only
- RHO participates in VxPx cargo-targeting to ciliumProteinReactome R-HSA-5620916Inferred only