Pathway
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Apoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and probably BNIP3L, AIFM2, STEAP3, TRIAP1 and TP53AIP1, thus promoting the activation of the apoptotic pathway.
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Transcriptional activation of TP53AIP1 requires phosphorylation of TP53 at serine residue S46. Phosphorylation of TP53 at S46 is regulated by another TP53 pro-apoptotic target, TP53INP1.
REACT:R-HSA-6803204Reactome
What the reference databases state
Statements
19 statements
19 statements · 1 reference database · Subject: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release · Sources: Reactome
- AIFM2 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- ATM participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- BAX participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- BID participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- BNIP3L participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- CREBBP participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- PMAIP1 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- PPP1R13B participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- PRELID1 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- PRELID3A participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- STEAP3 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- TP53 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
Show the remaining 7
- TP53AIP1 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- TP53BP2 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- TP53INP1 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- TP63 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- TP73 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- TRIAP1 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only
- ZNF420 participates in TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseProteinReactome R-HSA-6803204Inferred only