Pathway
Tie2 Signaling
The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
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These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.
REACT:R-HSA-210993Reactome
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: Tie2 Signaling · Sources: Reactome
- ANGPT1 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- ANGPT2 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- ANGPT4 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- DOK2 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- GRB14 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- GRB7 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- HRAS participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- NRAS participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- PIK3CA participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- PIK3CB participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- PIK3R1 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- PIK3R2 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
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- PTPN11 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- SHC1 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- SOS1 participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only
- TEK participates in Tie2 SignalingProteinReactome R-HSA-210993Inferred only