TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P

Mutations in transaldolase 1 (TALDO1), an enzyme of the pentose phosphate pathway that normally mediates the reversible interconversion of D-fructose 6-phosphate and D-erythrose 4-phosphate to form sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate, have been associated with congenital liver disease.

Summary from Reactome (R-HSA-6791462), read 2026-09-23.