Pathway
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Activation of the PI3K/mTOR, RAS/MAPK and STAT signaling pathways has been observed downstream of activated extracellular, juxtamembrane and kinase domain mutants of KIT, although downstream signaling has not been studied in great detail in all cases. Activation of these pathways contributes to cellular proliferation, avoidance of apoptosis, and actin cytoskeletal organization (Dunesing et al, 2004; Bauer et al, 2007; Chi et al, 2010; Bosbach et al, 2017; reviewed in Lennartsson and Roonstrand, 2012; Corless et al, 2011).
REACT:R-HSA-9670439Reactome
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants · Sources: Reactome
- FYN participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- HRAS participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- JAK2 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- KIT participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- LCK participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- LYN participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- NRAS participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- PIK3CA participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- PIK3R1 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- PIK3R2 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- PIK3R3 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- SOS1 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
Show the remaining 5
- STAT1 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- STAT3 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- STAT5A participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- STAT5B participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only
- YES1 participates in Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsProteinReactome R-HSA-9670439Inferred only