Pathway
Signaling by LTK in cancer
LTK is a member of the anaplastic lymphoma kinase (ALK)/LTK subfamily within the insulin receptor superfamily of RTKs. LTK encodes an 864-amino-acid protein consisting of extracellular, transmembrane, and tyrosine kinase domains and a short carboxy terminus. The LTK kinase domain shares 80% identity with ALK. The biological role of LTK is not well defined under normal physiological conditions, and unlike ALK, a clear role for LTK in cancer is also not yet well established. LTK is overexpressed in leukemia, and high expression of LTK in early-stage non-small cell lung cancer (NSCLC) has been associated with greater risk of metastasis. More recently, a novel CLIP1-LTK fusion protein has been identified in a small proportion of NSCLC cases.
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: Signaling by LTK in cancer · Sources: Reactome
- CLIP1 participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only
- MAPK1 participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only
- MAPK3 participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only
- PIK3CA participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only
- PIK3CB participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only
- PIK3R1 participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only
- PIK3R2 participates in Signaling by LTK in cancerProteinReactome R-HSA-9842640Inferred only