Pathway
Signaling by Ligand-Responsive EGFR Variants in Cancer
Ligand-responsive EGFR cancer variants harbor mutations in the kinase domain or point mutations in the extracellular domain. These altered EGFR proteins are able to signal in the absence of ligands, but their ligand binding ability is preserved and downstream signaling is potentiated when ligand is available.
REACT:R-HSA-5637815Reactome
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: Signaling by Ligand-Responsive EGFR Variants in Cancer · Sources: Reactome
- CBL participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- CDC37 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- EGF participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- EGFR participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- GAB1 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- HRAS participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- HSP90AA1 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- NRAS participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- PIK3CA participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- PIK3R1 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- PLCG1 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- RPS27A participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
Show the remaining 5
- SHC1 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- SOS1 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- UBA52 participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- UBB participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only
- UBC participates in Signaling by Ligand-Responsive EGFR Variants in CancerProteinReactome R-HSA-5637815Inferred only