Pathway
Signaling by KIT in disease
KIT signaling is important in several processes including stem cell maintenance, erythropoiesis, mast cell development, lymphopoiesis, melanogenesis and maintenance of interstitial cell of Cajal. Gain-of-function mutations in KIT have been identified at low frequency in a number of diseases, including AML, melanoma and mast and germ cell tumors, and at higher frequency in gastrointesinal stromal tumors (reviewed in Lennartsson and Roonstrand, 2012; Abbaspour Babaei et al, 2016; Roskoski, 2018).
REACT:R-HSA-9669938Reactome
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: Signaling by KIT in disease · Sources: Reactome
- FYN participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- HRAS participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- JAK2 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- KIT participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- LCK participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- LYN participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- NRAS participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- PIK3CA participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- PIK3R1 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- PIK3R2 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- PIK3R3 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- SOS1 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
Show the remaining 5
- STAT1 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- STAT3 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- STAT5A participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- STAT5B participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only
- YES1 participates in Signaling by KIT in diseaseProteinReactome R-HSA-9669938Inferred only