Pathway
Sensing of DNA Double Strand Breaks
Detection of DNA double-strand breaks (DSBs) involves sensor proteins of the MRN complex, composed of MRE11A, RAD50 and NBN (NBS1). Binding of the MRN complex to DNA DSBs activates ATM-dependent DNA damage signaling cascade, by promoting KAT5 (Tip60) mediated acetylation of ATM and subsequent ATM autophosphorylation. Activated ATM triggers and coordinates recruitment of repair proteins to DNA DSBs.
REACT:R-HSA-5693548Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Sensing of DNA Double Strand Breaks · Sources: Reactome
- ATM participates in Sensing of DNA Double Strand BreaksProteinReactome R-HSA-5693548Inferred only
- KAT5 participates in Sensing of DNA Double Strand BreaksProteinReactome R-HSA-5693548Inferred only
- KPNA2 participates in Sensing of DNA Double Strand BreaksProteinReactome R-HSA-5693548Inferred only
- MRE11 participates in Sensing of DNA Double Strand BreaksProteinReactome R-HSA-5693548Inferred only
- NBN participates in Sensing of DNA Double Strand BreaksProteinReactome R-HSA-5693548Inferred only
- RAD50 participates in Sensing of DNA Double Strand BreaksProteinReactome R-HSA-5693548Inferred only