Pathway
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Severe acute respiratory syndrome coronavirus type 1 (SARS‑CoV‑1) encodes several proteins that modulate host intracellular signaling and regulatory pathways. Among them are nucleocapsid N, membrane M and 3a proteins that directly bind to host targets associated with SARS‑CoV‑1 infection and cytokine production. This Reactome module describes several such binding events and their consequences. First, SARS‑CoV‑1 M binds to 3‑phosphoinositide‑dependent protein kinase 1 (PDPK1) to inhibit PKB/Akt activation. Second, SARS‑CoV‑1 N binds to SMAD3 to alter transforming growth factor‑β (TGF‑β) signaling. This interaction prevents SMAD3 from complexing with SMAD4, thereby blocking TGF-β-sensitized apoptosis. The association of N with SMAD3 also enhances the TGF-β-induced expression of PAI-1 (SERPINE1) promoting tissue fibrosis. Third, N protein binding to proteasome subunit p42 (PSMC6) modulates proteasome‑regulated degradation of proteins. Fourth, SARS‑CoV‑1 N binds SUMO-conjugating enzyme UBC9 (UBE2I) to regulate the activity of UBE2I, affecting downstream signaling factors involved in the cell cycle, in addition to its function in the process of sumoylation. Finally, binding of viral 3a to the regulator and scaffolding protein caveolin‑1 (CAV1) may regulate virus uptake as well as the trafficking of viral structural proteins.
What the reference databases state
Statements
15 statements
15 statements · 1 reference database · Subject: SARS-CoV-1 targets host intracellular signalling and regulatory pathways · Sources: Reactome
- CAV1 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- EP300 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- PDPK1 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- PSMC6 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- SFN participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- SMAD3 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- SMAD4 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- SP1 participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- UBE2I participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- YWHAB participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- YWHAE participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- YWHAG participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
Show the remaining 3
- YWHAH participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- YWHAQ participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only
- YWHAZ participates in SARS-CoV-1 targets host intracellular signalling and regulatory pathwaysProteinReactome R-HSA-9735871Inferred only