Pathway
RUNX3 regulates p14-ARF
Acetylation of RUNX3 by the histone acetyl transferase p300 (EP300) and the subsequent association of acetylated RUNX3 with BRD2 correlates with upregulation of p14-ARF transcription from the CDKN2A locus. Cyclin D1 (CCND1) negatively regulates RUNX3-facilitated induction of p14-ARF by recruiting histone deacetylase HDAC4 to RUNX3, leading to RUNX3 deacetylation.
REACT:R-HSA-8951936Reactome
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: RUNX3 regulates p14-ARF · Sources: Reactome
- BRD2 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- CBFB participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- CCND1 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- EP300 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- HDAC4 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- KRAS participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- RUNX1 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- RUNX3 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only
- TGFB1 participates in RUNX3 regulates p14-ARFProteinReactome R-HSA-8951936Inferred only