Pathway
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
The RUNX1:CBFB complex regulates expression of genes involved in differentiation of myeloid progenitors which can commit to hematopoietic lineages that lead to generation of platelets, erythrocytes, leukocytes or monocytes.
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The RUNX1:CBFB complex recruits histone acetyltransferase CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), thus inducing GM-CSF expression. GM-CSF induces growth, differentiation and survival of macrophages, granulocytes, erythrocytes and megakaryocytes from myeloid progenitors.
The RUNX1:CBFB complex directly stimulates transcription of the LGALS3 gene, encoding galectin-3. Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).
The PRKCB gene, encoding protein kinase C-beta, which regulates apoptosis of myeloid cells, is directly transactivated by the RUNX1:CBFB complex.
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: RUNX1 regulates transcription of genes involved in differentiation of myeloid cells · Sources: Reactome
- CBFB participates in RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsProteinReactome R-HSA-8939246Inferred only
- CREBBP participates in RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsProteinReactome R-HSA-8939246Inferred only
- CSF2 participates in RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsProteinReactome R-HSA-8939246Inferred only
- LGALS3 participates in RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsProteinReactome R-HSA-8939246Inferred only
- PRKCB participates in RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsProteinReactome R-HSA-8939246Inferred only
- RUNX1 participates in RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsProteinReactome R-HSA-8939246Inferred only