Pathway
RHOT2 GTPase cycle
This pathway catalogues guanine nucleotide exchange factors (GEFs) and effectors of RHOT2 (also known as MIRO-2). RHOT2 possesses a high intrinsic GTP-ase activity and does not require a GTPase activator protein (GAP). No GDP dissociation inhibitors (GDIs) have been reported to interact with RHOT2. RHOT2 is a mitochondrial RHO GTPase. Like related RHOT1 (MIRO-1), RHOT2 localizes to the outer mitochondrial membrane. Similar to RHOT1, RHOT2 regulates mitochondrial movement by coupling mitochondria to kinesin and dynein motors that transport them along microtubules. RHOT2 is also localized to peroxisomes and it is involved in peroxisomal dynamics.
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: RHOT2 GTPase cycle · Sources: Reactome
- MFN1 participates in RHOT2 GTPase cycleProteinReactome R-HSA-9013419Inferred only
- MFN2 participates in RHOT2 GTPase cycleProteinReactome R-HSA-9013419Inferred only
- RAP1GDS1 participates in RHOT2 GTPase cycleProteinReactome R-HSA-9013419Inferred only
- RHOT2 participates in RHOT2 GTPase cycleProteinReactome R-HSA-9013419Inferred only
- TRAK1 participates in RHOT2 GTPase cycleProteinReactome R-HSA-9013419Inferred only
- TRAK2 participates in RHOT2 GTPase cycleProteinReactome R-HSA-9013419Inferred only