Pathway
RHO GTPases regulate CFTR trafficking
Activated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing protein) also known as PIST, FIG or CAL. GOPC is a Golgi resident protein that binds several membrane proteins, thereby modulating their expression. In the absence of RHOQ, GOPC bound to CFTR directs CFTR for lysosomal degradation, while GTP-bound RHOQ directs GOPC:CFTR complex to the plasma membrane, thereby rescuing CFTR.
REACT:R-HSA-5627083Reactome
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: RHO GTPases regulate CFTR trafficking · Sources: Reactome
- CFTR participates in RHO GTPases regulate CFTR traffickingProteinReactome R-HSA-5627083Inferred only
- GOPC participates in RHO GTPases regulate CFTR traffickingProteinReactome R-HSA-5627083Inferred only
- RHOQ participates in RHO GTPases regulate CFTR traffickingProteinReactome R-HSA-5627083Inferred only