Pathway
Regulation of MITF-M dependent genes involved in metabolism
MITF contributes to cellular energetics by regulating the expression of genes such as PPARGC1A, a regulator of mitochondrial biogenesis. MITF-dependent PPARGC1A expression shifts cells towards oxidative phosphorylation. MITF also promotes the expression of SIRT1, an NAD-dependent deacetylase that acts as a rheostat for cellular energetics. SIRT1 contributes to proliferation and inhibition of senescence in part through its regulation of p300.
REACT:R-HSA-9854907Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: Regulation of MITF-M dependent genes involved in metabolism · Sources: Reactome
- PPARGC1A participates in Regulation of MITF-M dependent genes involved in metabolismProteinReactome R-HSA-9854907Inferred only
- SIRT1 participates in Regulation of MITF-M dependent genes involved in metabolismProteinReactome R-HSA-9854907Inferred only