Pathway
Regulation of MITF-M dependent genes involved in invasion
Targets of MITF such as CEACAM1, GMPR and DIAPH1 contribute to cellular mobility and invasion by affecting cellular adhesion and regulating the actin cytoskeleton. MITF also regulates expression of genes involved in EMT such as SNAI2. MITF-dependent changes in invasiveness are of particular interest in the context of melanoma (reviewed in Goding and Arnheiter, 2019; Cheli et al, 2010; White and Zon, 2008).
REACT:R-HSA-9854909Reactome
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: Regulation of MITF-M dependent genes involved in invasion · Sources: Reactome
- CEACAM1 participates in Regulation of MITF-M dependent genes involved in invasionProteinReactome R-HSA-9854909Inferred only
- DIAPH1 participates in Regulation of MITF-M dependent genes involved in invasionProteinReactome R-HSA-9854909Inferred only
- GMPR participates in Regulation of MITF-M dependent genes involved in invasionProteinReactome R-HSA-9854909Inferred only