Regulation of gap junction activity

Src is believed to suppress gap junction communication by phosphorylating Cx43. The kinases c-Src, PKc and MAPK play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating.

Summary from Reactome (R-HSA-191650), read 2026-09-23.