Pathway
PLCG1 events in ERBB2 signaling
Activation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR, and potentially Y1023 in the C-tail of ERBB2.
REACT:R-HSA-1251932Reactome
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: PLCG1 events in ERBB2 signaling · Sources: Reactome
- EGF participates in PLCG1 events in ERBB2 signalingProteinReactome R-HSA-1251932Inferred only
- EGFR participates in PLCG1 events in ERBB2 signalingProteinReactome R-HSA-1251932Inferred only
- ERBB2 participates in PLCG1 events in ERBB2 signalingProteinReactome R-HSA-1251932Inferred only
- PLCG1 participates in PLCG1 events in ERBB2 signalingProteinReactome R-HSA-1251932Inferred only