Pathway

PKB-mediated events

PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.

Summary from Reactome (R-HSA-109703), read 2026-09-23.

REACT:R-HSA-109703Reactome

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What the reference databases state

Statements

2 statements

2 statements · 1 reference database · Subject: PKB-mediated events · Sources: Reactome

Order

AKT2 participates in PKB-mediated eventsProteinReactome R-HSA-109703Inferred only
PDE3B participates in PKB-mediated eventsProteinReactome R-HSA-109703Inferred only