Pathway
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
After phosphorylated BMAL1:CLOCK heterodimers bind E-box elements in the promoters of target genes, CLOCK acetylates BMAL1 (inferred from mouse homologs in Hirayama et al. 2007) and becomes hyperphosphorylated through an incompletely characterized mechanism (inferred from the mouse homolog in Yoshitane et al. 2009, Robles et al. 2017). The hyperphosphorylation appears to both increase transcriptional activation activity and increase proteolytic degradation of CLOCK.
REACT:R-HSA-9931512Reactome
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters · Sources: Reactome
- BMAL1 participates in Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promotersProteinReactome R-HSA-9931512Inferred only
- CLOCK participates in Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promotersProteinReactome R-HSA-9931512Inferred only
- CREBBP participates in Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promotersProteinReactome R-HSA-9931512Inferred only
- KMT2A participates in Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promotersProteinReactome R-HSA-9931512Inferred only