Pathway
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Post-translational modifications of circadian clock proteins provide additional levels of tempo control and metabolic control, as well as mechanisms for terminating transcriptional activation and activating proteolysis (reviewed in Lee et al. 2001, Hirano et al 2016, Alessandro et al. 2019).
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After BMAL1 (ARNTL) and CLOCK are synthesized in the cytosol, CDK5 phosphorylates CLOCK (inferred from mouse homologs in Kwak et al. 2013) and CSNK2A1 (CK2alpha) phosphorylates BMAL1 (inferred from mouse homologs in Tamaru et al. 2009, Tamaru et al. 2015). The phosphorylated BMAL1 and CLOCK proteins heterodimerize (inferred from mouse homologs in Kondratov et al. 2003, Tamaru et al 2015) and are translocated to the nucleoplasm (inferred from mouse homologs in Tamaru et al. 2003, Kondratov et al. 2006, Kwon et al. 2006). NPAS2 can also heterodimerize with BMAL1 and is presumed to undergo similar phosphorylation, however, this has not been directly demonstrated.
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK · Sources: Reactome
- BMAL1 participates in Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCKProteinReactome R-HSA-9931529Inferred only
- CDK5 participates in Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCKProteinReactome R-HSA-9931529Inferred only
- CLOCK participates in Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCKProteinReactome R-HSA-9931529Inferred only
- CSNK2A1 participates in Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCKProteinReactome R-HSA-9931529Inferred only
- CSNK2B participates in Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCKProteinReactome R-HSA-9931529Inferred only