Pathway
PDE3B signalling
AKT (PKB) is recruited to the plasma membrane by binding phosphatidylinositol (3,4,5)-trisphosphate (PIP3). AKT is then activated by phosphorylation. Activated AKT in turn phosphorylates Phosphodiesterase 3B (PDE3B) which hydrolyzes 3',5'-cyclic AMP (cAMP) (reviewed in Manning and Toker 2017).
REACT:R-HSA-165160Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: PDE3B signalling · Sources: Reactome
- AKT2 participates in PDE3B signallingProteinReactome R-HSA-165160Inferred only
- PDE3B participates in PDE3B signallingProteinReactome R-HSA-165160Inferred only