Pathway

p75NTR negatively regulates cell cycle via SC1

SC1 (Schwann Cell factor 1; also called PR domain zinc finger protein 4, PRDM4) interacts with an NGF:p75NTR complex and signals cell cycle arrest by regulating the levels of cyclin E.

Summary from Reactome (R-HSA-193670), read 2026-09-23.

REACT:R-HSA-193670Reactome

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What the reference databases state

Statements

6 statements

6 statements · 1 reference database · Subject: p75NTR negatively regulates cell cycle via SC1 · Sources: Reactome

Order

HDAC1 participates in p75NTR negatively regulates cell cycle via SC1ProteinReactome R-HSA-193670Inferred only
HDAC2 participates in p75NTR negatively regulates cell cycle via SC1ProteinReactome R-HSA-193670Inferred only
HDAC3 participates in p75NTR negatively regulates cell cycle via SC1ProteinReactome R-HSA-193670Inferred only
NGF participates in p75NTR negatively regulates cell cycle via SC1ProteinReactome R-HSA-193670Inferred only
NGFR participates in p75NTR negatively regulates cell cycle via SC1ProteinReactome R-HSA-193670Inferred only
PRDM4 participates in p75NTR negatively regulates cell cycle via SC1ProteinReactome R-HSA-193670Inferred only