Pathway
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Liver X receptors NR1H3 (LXR alpha) and NR1H2 (LXR beta) are sterol-responsive transcription factors that become activated upon the engagement with their cognate oxysterol ligands. Besides inducing a genetic program aimed to reduce the cellular sterol load, ligand-activated NR1H2 & NR1H3 also modulate the expression and activity of genes controlling bile acid synthesis, transport and metabolism such as bile acid-glucuronidating enzyme UGT1A3 which converts hydrophobic bile acids into polar metabolites that can be excreted in the urine (Verreault M et al. 2006).
REACT:R-HSA-9623433Reactome
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis · Sources: Reactome
- FABP6 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- NCOA1 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- NCOR1 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- NCOR2 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- NR1H2 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- NR1H3 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- RXRA participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- RXRB participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only
- UGT1A3 participates in NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasisProteinReactome R-HSA-9623433Inferred only