Pathway
NFE2L2 regulating ER-stress associated genes
Subpathway representing ER-stress-associated genes regulated by NFE2L2 (NRF2). Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of adaptive genes that allow cells to endure periods of stress, such as hypoxia or amino acid limitation. However, under persistent stress conditions, ATF4 promotes the induction of apoptosis. ATF4 is also known to regulate serine and glycine biosynthesis in NSCLC
REACT:R-HSA-9818035Reactome
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: NFE2L2 regulating ER-stress associated genes · Sources: Reactome
- ATF4 participates in NFE2L2 regulating ER-stress associated genesProteinReactome R-HSA-9818035Inferred only
- CREBBP participates in NFE2L2 regulating ER-stress associated genesProteinReactome R-HSA-9818035Inferred only
- EP300 participates in NFE2L2 regulating ER-stress associated genesProteinReactome R-HSA-9818035Inferred only
- MAFK participates in NFE2L2 regulating ER-stress associated genesProteinReactome R-HSA-9818035Inferred only
- NFE2L2 participates in NFE2L2 regulating ER-stress associated genesProteinReactome R-HSA-9818035Inferred only