Pathway

MET activates PI3K/AKT signaling

MET binds and phosphorylates the adapter protein GAB1, thus creating a docking site for the regulatory subunit PIK3R1 of the PI3K complex. Recruitment of PI3K to MET-bound phosphorylated GAB1 results in PI3K activation, production of PIP3, and stimulation of downstream AKT signaling.

Summary from Reactome (R-HSA-8851907), read 2026-09-23.

REACT:R-HSA-8851907Reactome

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What the reference databases state

Statements

5 statements

5 statements · 1 reference database · Subject: MET activates PI3K/AKT signaling · Sources: Reactome

Order

GAB1 participates in MET activates PI3K/AKT signalingProteinReactome R-HSA-8851907Inferred only
HGF participates in MET activates PI3K/AKT signalingProteinReactome R-HSA-8851907Inferred only
MET participates in MET activates PI3K/AKT signalingProteinReactome R-HSA-8851907Inferred only
PIK3CA participates in MET activates PI3K/AKT signalingProteinReactome R-HSA-8851907Inferred only
PIK3R1 participates in MET activates PI3K/AKT signalingProteinReactome R-HSA-8851907Inferred only