Pathway
Loss of MECP2 binding ability to 5mC-DNA
Missense mutations in the methyl-CpG binding domain (MBD) of methyl-CpG-binding protein 2 (MECP2), spanning amino acids 90 to 162, negatively affect the binding ability of MECP2 to methylated DNA.
REACT:R-HSA-9022538Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: Loss of MECP2 binding ability to 5mC-DNA · Sources: Reactome
- HDAC1 participates in Loss of MECP2 binding ability to 5mC-DNAProteinReactome R-HSA-9022538Inferred only
- SIN3A participates in Loss of MECP2 binding ability to 5mC-DNAProteinReactome R-HSA-9022538Inferred only