Pathway
Interleukin-36 pathway
Interleukin-36 alpha (IL36A), IL36B and IL36G are collectively known as IL36. They are members of the Interlukin-1 family that signal through a receptor composed of Interleukin-1 receptor-like 2 (IL1RL2, IL36R) and Interleukin-1 receptor accessory protein (IL1RAP, IL-1R/AcP) to promote inflammatory responses. Interleukin-36 receptor antagonist protein (IL36RN, IL36Ra) is a natural antagonist. IL36 is expressed predominantly by epithelial cells and is implicated strongly through functional and genetic evidence in the pathology of psoriatic disorders.
REACT:R-HSA-9014826Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Interleukin-36 pathway · Sources: Reactome
- IL1F10 participates in Interleukin-36 pathwayProteinReactome R-HSA-9014826Inferred only
- IL1RL2 participates in Interleukin-36 pathwayProteinReactome R-HSA-9014826Inferred only
- IL36A participates in Interleukin-36 pathwayProteinReactome R-HSA-9014826Inferred only
- IL36B participates in Interleukin-36 pathwayProteinReactome R-HSA-9014826Inferred only
- IL36G participates in Interleukin-36 pathwayProteinReactome R-HSA-9014826Inferred only
- IL36RN participates in Interleukin-36 pathwayProteinReactome R-HSA-9014826Inferred only