Highly sodium permeable postsynaptic acetylcholine nicotinic receptors

Nicotinic acetylcholne receptors that have low Ca2+ permeability allow the influx of Na+ which causes depolarization of the membrane initiating voltage dependent responses such as activation of voltage dependent opening of Ca2+ channels and thus eliciting an increase in Ca2+ and downstream signaling. These receptors could be found in both presynaptic and postsynaptic terminals.

Summary from Reactome (R-HSA-629587), read 2026-09-23.