Pathway

Erythropoietin activates Phospholipase C gamma (PLCG)

PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activated EPOR is phosphorylated on tyrosine residues by the kinase LYN (Ren et al. 1994, and inferred from mouse homologs). PLCG1 and PLCG2 produce inositol 1,4,5-trisphosphate which then activates calcium signaling, and diacylglycerol (DAG) which then activates protein kinase C (PKC).

Summary from Reactome (R-HSA-9027277), read 2026-09-23.

REACT:R-HSA-9027277Reactome

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What the reference databases state

Statements

7 statements

7 statements · 1 reference database · Subject: Erythropoietin activates Phospholipase C gamma (PLCG) · Sources: Reactome

Order

EPO participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only
EPOR participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only
IRS2 participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only
JAK2 participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only
LYN participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only
PLCG1 participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only
PLCG2 participates in Erythropoietin activates Phospholipase C gamma (PLCG)ProteinReactome R-HSA-9027277Inferred only