Pathway
Energy dependent regulation of mTOR by LKB1-AMPK
Upon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. This phosphorylation is immediately removed in basal conditions by PP2C, but if the cellular AMP:ATP ratio rises, this activation is maintained, as AMP binding by AMPK inhibits the dephosphorylation. AMPK then activates the TSC complex by phosphorylating TSC2. Active TSC activates the intrinsic GTPase activity of Rheb, resulting in GDP-loaded Rheb and inhibition of mTOR pathway.
REACT:R-HSA-380972Reactome
What the reference databases state
Statements
29 statements
29 statements · 1 reference database · Subject: Energy dependent regulation of mTOR by LKB1-AMPK · Sources: Reactome
- CAB39 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- CAB39L participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- LAMTOR1 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- LAMTOR2 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- LAMTOR3 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- LAMTOR4 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- LAMTOR5 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- MLST8 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- MTOR participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PPM1A participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PRKAA1 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PRKAA2 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
Show the remaining 17
- PRKAB1 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PRKAB2 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PRKAG1 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PRKAG2 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- PRKAG3 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- RHEB participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- RPTOR participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- RRAGA participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- RRAGB participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- RRAGC participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- RRAGD participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- SLC38A9 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- STK11 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- STRADA participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- STRADB participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- TSC1 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only
- TSC2 participates in Energy dependent regulation of mTOR by LKB1-AMPKProteinReactome R-HSA-380972Inferred only