Pathway
Biosynthesis of protectins
Docosahexaenoic acid (DHA), a major ω-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of protectins (PDs), one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions. The switch from synthesis of pro-inflammatory eicosanoids, such as the prostaglandins and the thromboxanes, to the pro-resolving lipoxins, resolvins and protectins, occurs via induction of the 15-lipoxygenase enzyme.
Continue reading
Protectin, identified as (N)PD1 (N signifies neuroprotectin when produced in neural tissues) is derived from DHA through the actions of 15-lipoxygenase then enzymatic hydrolysis. Aspirin can also trigger the formation of epimeric protectin (AT-PD1). An additional protectin (DX) is formed through the sequential actions of two lipoxygenase reactions. The biosynthesis of these protectins is described here.
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: Biosynthesis of protectins · Sources: Reactome
- ALOX15 participates in Biosynthesis of protectinsProteinReactome R-HSA-9018681Inferred only
- CYP1A1 participates in Biosynthesis of protectinsProteinReactome R-HSA-9018681Inferred only
- CYP1A2 participates in Biosynthesis of protectinsProteinReactome R-HSA-9018681Inferred only
- LTA4H participates in Biosynthesis of protectinsProteinReactome R-HSA-9018681Inferred only