Pathway
Biosynthesis of maresin-like SPMs
Maresin-like mediators MaR-L1, Mar-L2 and 14,21-dihydroxy docosahexaenoic acids are normally synthesized by leukocytes, platelets and macrophages, via the pathways described here. Impaired production of these specialised proresolving mediators (SPMs) in diabetic skin wounds is associated with impaired macrophage function and delayed or absent wound healing. Macrophages play critical roles in wound healing by mechanisms as yet unknown. They are active in both the initiation (M1 macrophage phenotype) and the resolution (M2 macrophage phenotype) of inflammatory processes. In a pathological state, the switch from the M1 phenotype macrophage to the M2 phenotype macrophage may be delayed or fail to occur, which can result in chronic low-grade inflammation. This macrophage phenotype skewing toward an inflammatory phenotype has been implicated in the pathogenesis of type 2 diabetes (T2D) and the non-healing of diabetic wounds.
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Administration of maresin-like SPMs to diabetic mice with induced wounds have been shown to act as autocrine/paracrine factors in restoring reparative functions of macrophages (Hong et al. 2014, Tian et al. 2011a, 2011b, Lu et al. 2010, Hellman et al. 2012).
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Biosynthesis of maresin-like SPMs · Sources: Reactome
- CYP1A2 participates in Biosynthesis of maresin-like SPMsProteinReactome R-HSA-9027307Inferred only
- CYP2C8 participates in Biosynthesis of maresin-like SPMsProteinReactome R-HSA-9027307Inferred only
- CYP2C9 participates in Biosynthesis of maresin-like SPMsProteinReactome R-HSA-9027307Inferred only
- CYP2D6 participates in Biosynthesis of maresin-like SPMsProteinReactome R-HSA-9027307Inferred only
- CYP2E1 participates in Biosynthesis of maresin-like SPMsProteinReactome R-HSA-9027307Inferred only
- CYP3A4 participates in Biosynthesis of maresin-like SPMsProteinReactome R-HSA-9027307Inferred only