Pathway
Biosynthesis of DPAn-3 SPMs
The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-docosapentaenoic acid (DPAn-3) is an intermediate in the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA) and is also a precursor for the production of novel bioactive mediators. The proposed biosynthesis of specialised proresolving mediators (SPMs) derived from DPAn-3 is described here. The products of the ω-3 isomer were characterised based on DHA (docosahexaenoic acid) derived resolvins, protectins and maresins. The same biosynthetic route as DHA-derived SPMs is probably how DPAn-3 products are also formed.
REACT:R-HSA-9025094Reactome
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: Biosynthesis of DPAn-3 SPMs · Sources: Reactome
- ALOX12 participates in Biosynthesis of DPAn-3 SPMsProteinReactome R-HSA-9025094Inferred only
- ALOX15 participates in Biosynthesis of DPAn-3 SPMsProteinReactome R-HSA-9025094Inferred only
- ALOX5 participates in Biosynthesis of DPAn-3 SPMsProteinReactome R-HSA-9025094Inferred only
- PTGS2 participates in Biosynthesis of DPAn-3 SPMsProteinReactome R-HSA-9025094Inferred only