Pathway
Biosynthesis of DPAn-3-derived maresins
The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-docosapentaenoic acid (DPAn-3) is an intermediate in the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA) and is also a precursor for the production of novel bioactive mediators.The proposed biosynthesis of maresins derived from DPAn-3 is described here. 12-lipoxygenase oxygenates DPAn-3 to its 14(S) hydroperoxy epimer from which maresins are formed via a combination of oxygenation, reduction and hydrolysis reactions. The products of the ω-3 isomer were characterised based on docosahexaenoic acid (DHA)-derived maresins and were demonstrated to have similar potent systemic anti-inflammatory and tissue protective actions as DHA-derived specialised proresolving mediators (SPMs). The same biosynthetic route as DHA-derived SPMs is probably how DPAn-3 products are also formed.
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: Biosynthesis of DPAn-3-derived maresins · Sources: Reactome
- ALOX12 participates in Biosynthesis of DPAn-3-derived maresinsProteinReactome R-HSA-9026290Inferred only
- ALOX5 participates in Biosynthesis of DPAn-3-derived maresinsProteinReactome R-HSA-9026290Inferred only