Pathway
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors (NMDARs) leads to activation of AMP-activated kinase (AMPK) in a CAMKK2-dependent manner. Overactivation of CAMKK2 or AMPK in neurons can lead to dendritic spine loss and is implicated in synaptotoxicity of beta-amyloids in Alzheimer's disease.
REACT:R-HSA-9619483Reactome
What the reference databases state
Statements
26 statements
26 statements · 1 reference database · Subject: Activation of AMPK downstream of NMDARs · Sources: Reactome
- CALM1 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- CAMKK2 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAA1 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAA2 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAB1 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAB2 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAG1 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAG2 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- PRKAG3 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA1A participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA1B participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA1C participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
Show the remaining 14
- TUBA3C participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA3D participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA3E participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA4A participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBA8 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBAL3 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB1 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB2A participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB2B participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB3 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB4A participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB4B participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB6 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only
- TUBB8 participates in Activation of AMPK downstream of NMDARsProteinReactome R-HSA-9619483Inferred only