Pathway
Activated NTRK3 signals through PI3K
The PI3K complex, composed of PIK3R1 and PIK3CA, co-immunoprecipitates with NTRK3 (TRKC), activated by NTF3 (NT-3) treatment. Activation of NTRK3 correlates with activating phosphorylation of AKT, the main mediator of PI3K signaling, and is dependent on PI3K activity. NTRK3-mediated activation of PI3K signaling depends on SRC activation and the adaptor protein IRS1, but the exact mechanism is not known.
REACT:R-HSA-9603381Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Activated NTRK3 signals through PI3K · Sources: Reactome
- IRS1 participates in Activated NTRK3 signals through PI3KProteinReactome R-HSA-9603381Inferred only
- NTF3 participates in Activated NTRK3 signals through PI3KProteinReactome R-HSA-9603381Inferred only
- NTRK3 participates in Activated NTRK3 signals through PI3KProteinReactome R-HSA-9603381Inferred only
- PIK3CA participates in Activated NTRK3 signals through PI3KProteinReactome R-HSA-9603381Inferred only
- PIK3R1 participates in Activated NTRK3 signals through PI3KProteinReactome R-HSA-9603381Inferred only
- SRC participates in Activated NTRK3 signals through PI3KProteinReactome R-HSA-9603381Inferred only