Pathway
Activated NTRK2 signals through PI3K
Neurotrophin receptor NTRK2 (TRKB), activated by BDNF or NTF4, activates PI3K, resulting in formation of the PIP3 secondary messenger. PIP3 activates AKT signaling, and AKT signaling activates mTOR signaling.
REACT:R-HSA-9028335Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Activated NTRK2 signals through PI3K · Sources: Reactome
- BDNF participates in Activated NTRK2 signals through PI3KProteinReactome R-HSA-9028335Inferred only
- GAB1 participates in Activated NTRK2 signals through PI3KProteinReactome R-HSA-9028335Inferred only
- NTF4 participates in Activated NTRK2 signals through PI3KProteinReactome R-HSA-9028335Inferred only
- NTRK2 participates in Activated NTRK2 signals through PI3KProteinReactome R-HSA-9028335Inferred only
- PIK3CA participates in Activated NTRK2 signals through PI3KProteinReactome R-HSA-9028335Inferred only
- PIK3R1 participates in Activated NTRK2 signals through PI3KProteinReactome R-HSA-9028335Inferred only