Pathway
Activated NTRK2 signals through FYN
In mouse brain, Fyn activation downstream of Bdnf-induced Ntrk2 (TrkB) signaling results in increased protein levels of AMPA receptor subunits Gria2 (GluR2), Gria3 (GluR3) and Gria1 (GluR1) without change in mRNA levels.
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BDNF-mediated activation of NTRK2 increases phosphorylation of voltage gated sodium channels by FYN, resulting in decrease of sodium currents.
FYN activation downstream of NTRK2 is implicated in olygodendrocyte myelination and contributes to BDNF-induced activation of ERK1/2 (MAPK3/1) through an unknown mechanism.
Besides acting downstream of NTRK2, FYN and other SRC kinases, activated by other receptors such as GPCRs, may phosphorylate NTRK2 and enhance its catalytic activity.
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Activated NTRK2 signals through FYN · Sources: Reactome
- BDNF participates in Activated NTRK2 signals through FYNProteinReactome R-HSA-9032500Inferred only
- DOCK3 participates in Activated NTRK2 signals through FYNProteinReactome R-HSA-9032500Inferred only
- GRIN2B participates in Activated NTRK2 signals through FYNProteinReactome R-HSA-9032500Inferred only
- NTRK2 participates in Activated NTRK2 signals through FYNProteinReactome R-HSA-9032500Inferred only
- RAC1 participates in Activated NTRK2 signals through FYNProteinReactome R-HSA-9032500Inferred only
- SRC participates in Activated NTRK2 signals through FYNProteinReactome R-HSA-9032500Inferred only