3,3'-diiodothyronamine

Three steps

• (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. 3'-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS1 and 1 more