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berberineFinding

Berberine decreases HOMA-IR

lowersModerate evidenceFindingreplicated ×5

01 · The sentence it was drawn from

“The meta-analysis findings support the conclusion that berberine exhibited a potential for reducing HOMA-IR levels (SMD = − 1.56. 95% CI [− 2.54, − 0.58], P = 0.002, I2 = 96%; Fig. 10).”
Quoted verbatim from The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review.
This finding among the 63 findings on its endpoint

berberine

HOMA-IR

lowers

Effect as reported

−1.56standardised mean difference

CI −2.54 to −0.58

Who
Adults with NAFLD in 5 pooled RCTs; berberine added to metformin in both-arm-metformin trials (patients with comorbid diabetes) or compared with lifestyle intervention or placebo
Dose studied
berberine 0.6 g to 2 g daily in 9 RCTs, 6.35 g daily in one; 7 to 24 weeks

Moderate evidencePMID 38429794 · 2024

02 · The study

Study
meta-analysis
Duration
not reported

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

Journal of translational medicine
What else it reported5 findings · 1 compound · 5 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZAE8WAVEJMKAP8PTDZH5Q5