Collagen peptides has no detected effect on transepidermal water loss (TEWL)

no difference foundModerate evidenceFinding

01 · The sentence it was drawn from

“Lesional stratum corneum hydration (F(1, 25) = 0.16, p = 0.694, d = 0.155), and lesional TEWL (F(1, 25) = 1.91, p = 0.179, d = 0.553), did not show statistically significant differences between the CP-G and P-G.”

Quoted verbatim from Oral Administration of Specific Bioactive Collagen Peptides in the Treatment of Moderate Forms of Atopic Dermatitis: A New Approach.

This finding among the 2 findings on its endpoint

collagen peptides

Transepidermal water loss (TEWL)

no difference found

Who: Adults with moderate atopic dermatitis (SCORAD 15-40), per-protocol population; lesional skin site; corticosteroid cream (triamcinolone) and body lotion permitted in both arms
Dose studied: 5 g daily, dissolved in 250 mL water

Moderate evidencePMID 41758763 · 2026

02 · The study

Study: RCT
Duration: 3 months

Evidence, by strength

strong
moderatethis finding
limited
very limited
insufficient

03 · The paper

Skin pharmacology and physiology

Oral Administration of Specific Bioactive Collagen Peptides in the Treatment of Moderate Forms of Atopic Dermatitis: A New Approach.

2026PMID 41758763doi 10.1159/000551215

What else it reported2 findings · 0 compounds · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6Y1Q9CQKARX3214A0A4PG8A