Creatine increases depression remission rate

raisesModerate evidenceFinding

01 · The sentence it was drawn from

“The remission rate at end point was higher in the creatine group than in the placebo group (odds ratio=6.92, SE=5.07, p=0.008) (online supplemental Figure SF2).”

Quoted verbatim from A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.

This finding among the 2 findings on its endpoint

creatine

Depression remission rate

raises

Effect as reported

6.92odds ratio

Who: Women aged 19-65 with major depressive disorder, a current major depressive episode and a 17-item HAM-D score of 16 or greater; escitalopram (10 mg/day for week 1, then 20 mg/day, adjustable) given to both arms
Dose studied: creatine monohydrate 3 g/day for the first week, then 5 g/day for 7 weeks, added to escitalopram

Moderate evidencePMID 22864465 · 2012

02 · The study

Study: RCT
Duration: 8 weeks

Evidence, by strength

strong
moderatethis finding
limited
very limited
insufficient

03 · The paper

The American journal of psychiatry

A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.

2012PMID 22864465doi 10.1176/appi.ajp.2012.12010009

What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6WF4MCXTA11NYGHXP12RMTN