Zollinger-Ellison syndrome
MONDO:0019610Mondo
Findings
No curated finding names Zollinger-Ellison syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Zollinger-Ellison syndrome (ZES) is characterized by severe peptic disease (ulcers/esophageal disease) caused by hypergastrinemia secondary to a gastrinoma resulting in increased gastric acid secretion.
Definition from the Mondo Disease Ontology (MONDO:0019610), read 2026-09-29. CC BY 4.0.
Features
34 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Neuroendocrine neoplasmHPOHP:0100634
- Obligate (100% of cases)
- Zollinger-Ellison syndromeHPOHP:0002044
- Obligate (100% of cases)
- DiarrheaHPOHP:0002014
- Very frequent (80% to 99% of cases)
- Duodenal ulcerHPOHP:0002588
- Very frequent (80% to 99% of cases)
- Episodic abdominal painHPOHP:0002574
- Very frequent (80% to 99% of cases)
- EsophagitisHPOHP:0100633
- Very frequent (80% to 99% of cases)
- NauseaHPOHP:0002018
- Very frequent (80% to 99% of cases)
- Peptic ulcerHPOHP:0004398
- Very frequent (80% to 99% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Adrenocortical adenomaHPOHP:0008256
- Occasional (5% to 29% of cases)
- Elevated circulating growth hormone concentrationHPOHP:0000845
- Occasional (5% to 29% of cases)
- Elevated circulating parathyroid hormone levelHPOHP:0003165
- Occasional (5% to 29% of cases)
Show the remaining 22
- ErythemaHPOHP:0010783
- Occasional (5% to 29% of cases)
- Extrahepatic cholestasisHPOHP:0012334
- Occasional (5% to 29% of cases)
- Gastrointestinal hemorrhageHPOHP:0002239
- Occasional (5% to 29% of cases)
- GlucagonomaHPOHP:0030404
- Occasional (5% to 29% of cases)
- HematocheziaHPOHP:0002573
- Occasional (5% to 29% of cases)
- HypercalcemiaHPOHP:0003072
- Occasional (5% to 29% of cases)
Where it sits
Other names
2 names
Resolves to: Zollinger-Ellison syndrome
- Also called
- Zollinger Ellison syndromeZollinger-Ellison syndrome (disease)