Zimmermann-Laband syndrome
Findings
No curated finding names Zimmermann-Laband syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare disorder characterized by gingival fibromatosis, coarse facial appearance, and absence or hypoplasia of nails or terminal phalanges of hands and feet.
Definition from the Mondo Disease Ontology (MONDO:0000200), read 2026-09-29. CC BY 4.0.
Features
43 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Gingival fibromatosisHPOHP:0000169
- Obligate (100% of cases)
- Absent fingernailHPOHP:0001817
- Frequent (30% to 79% of cases)
- Anterior open-bite malocclusionHPOHP:0009102
- Frequent (30% to 79% of cases)
- Bulbous noseHPOHP:0000414
- Frequent (30% to 79% of cases)
- Generalized hypertrichosisHPOHP:0004554
- Frequent (30% to 79% of cases)
- Hypoplastic fingernailHPOHP:0001804
- Frequent (30% to 79% of cases)
- Intellectual disabilityHPOHP:0001249
- Frequent (30% to 79% of cases)
- Joint hypermobilityHPOHP:0001382
- Frequent (30% to 79% of cases)
- Large fleshy earsHPOHP:0002265
- Frequent (30% to 79% of cases)
- Thickened earsHPOHP:0009894
- Frequent (30% to 79% of cases)
- Wide mouthHPOHP:0000154
- Frequent (30% to 79% of cases)
- Wide noseHPOHP:0000445
- Frequent (30% to 79% of cases)
Show the remaining 31
- Abnormal cardiovascular system morphologyHPOHP:0030680
- Occasional (5% to 29% of cases)
- Abnormal external genitalia morphologyHPOHP:0000811
- Occasional (5% to 29% of cases)
- Bifid uvulaHPOHP:0000193
- Occasional (5% to 29% of cases)
- CataractHPOHP:0000518
- Occasional (5% to 29% of cases)
- Cleft palateHPOHP:0000175
- Occasional (5% to 29% of cases)
- Downslanted palpebral fissuresHPOHP:0000494
- Occasional (5% to 29% of cases)
Genes
3 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of
Other names
5 names
Resolves to: Zimmermann-Laband syndrome
- Also called
- gingival fibromatosis-hepatosplenomegaly-other anomalies syndromeLaband syndromeZimmerman Laband syndromeZimmermann-Laband syndrome type 1ZLS