Wolff-Parkinson-White syndrome
Findings
No curated finding names Wolff-Parkinson-White syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes.
Definition from the Mondo Disease Ontology (MONDO:0008685), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset · Young adult onset · Childhood onset
HPO, annotations 2026-09-02
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Ventricular preexcitationHPOHP:0004309
- 27 of 27 reported patients
- Wolff-Parkinson-White syndromeHPOHP:0001716
- 35 of 35 reported patients
- Atrial flutterHPOHP:0004749
- 2 of 3 reported patients
- SyncopeHPOHP:0001279
- 14 of 26 reported patients
- Paroxysmal atrial fibrillationHPOHP:0004757
- 15 of 34 reported patients
- Ventricular preexcitation with multiple accessory pathwaysHPOHP:0006684
- 2 of 8 reported patients
- Sudden cardiac deathHPO
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- PRKAG2HGNC:9386
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
Where it sits
Other names
4 names
Resolves to: Wolff-Parkinson-White syndrome
- Also called
- ventricular familial preexcitation syndromeWolff-Parkinson-White pattern (finding)Wolff-Parkinson-white syndrome (disease)WPW