Whipple disease
MONDO:0005116Mondo
Findings
No curated finding names Whipple disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A systemic infection caused by the Gram-positive bacterium Tropheryma whipplei. It affects the small intestine resulting in malabsorption. Other sites or systems affected by the infection are the joints, central nervous system, and the cardiovascular system.
Definition from the Mondo Disease Ontology (MONDO:0005116), read 2026-09-29. CC BY 4.0.
Features
47 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abdominal painHPOHP:0002027
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- ArthritisHPOHP:0001369
- Very frequent (80% to 99% of cases)
- CachexiaHPOHP:0004326
- Very frequent (80% to 99% of cases)
- DepressionHPOHP:0000716
- Very frequent (80% to 99% of cases)
- Developmental regressionHPOHP:0002376
- Very frequent (80% to 99% of cases)
- DiarrheaHPOHP:0002014
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- MalabsorptionHPOHP:0002024
- Very frequent (80% to 99% of cases)
- Mediastinal lymphadenopathyHPOHP:0100721
- Very frequent (80% to 99% of cases)
Show the remaining 35
- MyoclonusHPOHP:0001336
- Very frequent (80% to 99% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- HypotensionHPOHP:0002615
- Frequent (30% to 79% of cases)
- MyalgiaHPOHP:0003326
- Frequent (30% to 79% of cases)
- PleuritisHPOHP:0002102
- Frequent (30% to 79% of cases)
- Sleep disturbanceHPOHP:0002360
- Frequent (30% to 79% of cases)
Where it sits
Other names
6 names
Resolves to: Whipple disease
- Also called
- intestinal lipodystrophyintestinal lipophagic granulomatosissecondary non-tropical sprueTropheryma whipplei caused disease or disorderTropheryma whipplei disease or disorderTropheryma whipplei infectious disease